Measuring dynamic and real-time cAMP levels

Measuring dynamic and real-time cAMP levels using cADDis Paul Tewson, Scott Martinka, Catherine Berlot, Thom Hughes, Anne Marie Quinn & Shane Tillo Real-Time cAMP Detection Here, we introduce a new fluorescent cAMP sensor, cADDis, capable of detecting dynamic changes...

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ASCB 2016

We are showcasing our newest and brightest live cell fluorescent indicators for cell signaling at ASCB 2016. Happening at ASCB 2016 Annual Meeting: Theater 2 Tech Talk: Monday Dec. 5, 8:30 - 8:45am “Measuring dynamic cAMP levels with improved sensitivity using cADDis,...

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cADDis – A New Handle on Cilia Signaling

The Proceedings of the National Academy of Sciences published another new scientific breakthrough made possible with our cADDis fluorescent biosensors. Montana Molecular’s genetically-encoded fluorescent biosensors are designed to indicate changes in cell signals with changes in fluorescence intensity and provide a window into the hidden machinery of the living cell.

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BIO International Convention 2016

Wednesday June 8, 2016 11:30 am, Room 3 We will also be hosting a kiosk in the NSF/NIH Sponsored Innovation Zone (Look for the Moose!) The more we learn about the mechanisms of drug activity, the more we realize that these mechanisms are far more nuanced than ever...

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Basel Life Science Week

Basel Life Science Week Montana Molecular's own Dr. T. Hughes will be presenting at the Basel Life Science Week GPCR Forum in Basel, Switzerland. Fluorescent biosensors for multicolored views of GPCR signaling will be presented at 11am, Sept. 24, 2015 in Room 4 at the...

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ArcLight Voltage Sensor

ArcLight Voltage Sensor[fruitful_sep] A  genetically-encoded, fluorescent voltage sensing protein in a BacMam viral delivery system is a noninvasive, easy-to-use tool for studying the electrical activity of live neurons.  To learn more about the development of voltage...

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PHASE II SBIR Funding Awarded to Montana Molecular

$1.1 million investment from the National Institutes of Health advances next generation tools for drug discovery in living cells. Montana Molecular, a privately-held company developing next generation tools for drug discovery in living cells, has been...

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DAG sensor illuminates TRPC6 Regulation

Montana Molecular’s DAG sensor helped unravel the molecular mechanisms of TRPC6 cation channel activity which could lead to new treatments for TRPC6-associated diseases that affect cardiovascular and kidney dysfunction…

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Wondering about BacMam in your favorite cell type?

BacMam technology is evolving and transduction efficiencies have improved substantially since many of these pioneering papers were published.  This body of work provides a summary of what has been accomplished and a starting point for assay optimization in...

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