Next-generation drugs for the evolving SARS-CoV-2 virus
Next-generation drugs for the evolving SARS-CoV-2 virusThere is increasing evidence that new variants of SARS-CoV-2 are appearing that cannot be treated with Paxlovid. This means that the next generation of antivirals will soon be needed to reduce the severity of...
Form and Function: consequences of subcellular cAMP signaling revealed
In a recent paper, Isabella Cattani-Cavalieri and her colleagues in Ren Ostrom’s laboratory found a new, powerful way to examine the functional consequences of different cAMP signalsomes (Cattani-Cavalieri et al., 2023). There has long been a suspicion that there are...
A breathtaking model for the cellular detection of hypoxia
In a recent paper, Peng and colleagues (Peng et al. 2023) use a variety of new approaches, and fresh ideas, to create a molecular model for how the cells of the carotid body sense the oxygen levels in our blood and use this to control our breathing. Surprisingly, key...
PIP2 biosensor used in new research on the regulation of cold sensitivity in DRG neurons.
In a bioRxiv preprint titled, “Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation”, graduate student Luyu Liu of Tibor Rohacs’ lab (rohacslab.org) at Rutgers Medical School and her colleagues explore how PIP2 levels, Ca2+, and the G-protein Gαq, converge to regulate activity of the cationic TRPM8 channel, which is normally activated by cold temperatures and chemical agonists such as menthol.
GLP-1 sends PKC-dependent signals
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation A new Journal of Clinical Investigation paper from Patrik Rorsman's group provides key insights into signaling mechanisms of GLP-1, a peptide that enhances insulin secretion and is the...
FPX Biosensors for Live Cell Imaging Published
First there was FRET, now there is FPX
Drug Discovery News
Biotek Scientific Director likes Montana Molecular’s live cell assays: “These sensors can be used for the simultaneous detection of all these second messengers. That is something that is really unique and really powerful, specifically for drug discovery efforts for GPCRs.”
Single fluorophore sensors for monitoring cell signaling networks
If you do nothing else today, set up a Google Profile. It takes maybe five minutes. Google Scholar uses the information in your profile, comprised of all the papers you've published, and all the papers that have referenced your papers, to figure out the papers you...
Sensing voltage on Electric Peak
Made in Montana, Electric Peak is the fastest genetically encoded voltage sensor to date, and is brought to you by Thom Hughes' Lab at Montana State University.
Light Activated Lipids
Activating a signaling pathway with light is one of the brightest ideas to come along. Pietro de Camilli's and Bertil Hille's labs collaborated on a brilliant example of this illuminating technique! Optogenetic control of phosphoinositide metabolism describes...