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Next-generation drugs for the evolving SARS-CoV-2 virus

Next-generation drugs for the evolving SARS-CoV-2 virus

Next-generation drugs for the evolving SARS-CoV-2 virusThere is increasing evidence that new variants of SARS-CoV-2 are appearing that cannot be treated with Paxlovid.  This means that the next generation of antivirals will soon be needed to reduce the severity of...

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A breathtaking model for the cellular detection of hypoxia

A breathtaking model for the cellular detection of hypoxia

In a recent paper, Peng and colleagues (Peng et al. 2023) use a variety of new approaches, and fresh ideas, to create a molecular model for how the cells of the carotid body sense the oxygen levels in our blood and use this to control our breathing. Surprisingly, key...

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PIP2 biosensor used in new research on the regulation of cold sensitivity in DRG neurons.

PIP2 biosensor used in new research on the regulation of cold sensitivity in DRG neurons.

In a bioRxiv preprint titled, “Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation”, graduate student Luyu Liu of Tibor Rohacs’ lab (rohacslab.org) at Rutgers Medical School and her colleagues explore how PIP2 levels, Ca2+, and the G-protein Gαq, converge to regulate activity of the cationic TRPM8 channel, which is normally activated by cold temperatures and chemical agonists such as menthol.

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GLP-1 sends PKC-dependent signals

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation A new Journal of Clinical Investigation paper from Patrik Rorsman's group provides key insights into signaling mechanisms of GLP-1, a peptide that enhances insulin secretion and is the...

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Drug Discovery News

Biotek Scientific Director likes Montana Molecular’s live cell assays: “These sensors can be used for the simultaneous detection of all these second messengers. That is something that is really unique and really powerful, specifically for drug discovery efforts for GPCRs.”

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Sensing voltage on Electric Peak

Made in Montana, Electric Peak is the fastest genetically encoded voltage sensor to date, and is brought to you by Thom Hughes' Lab at Montana State University.

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Light Activated Lipids

Activating a signaling pathway with light is one of the brightest ideas to come along. Pietro de Camilli's and Bertil Hille's labs collaborated on a brilliant example of this illuminating technique! Optogenetic control of phosphoinositide metabolism describes...

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