GPCR Signaling Kinetics
Data Analysis
Time course equations for a variety of curve shapes entered into GraphPad Prism as a plug-in.
Parameters include:
-
- Initial rate of signal generation
- Fade (desensitization) rate
- Steady-State signal level
- Peak level and peak time
References
![data-analysis-fig-1](https://montanamolecular.com/wp-content/uploads/2023/02/data-analysis-fig-1.jpg)
Rise and fall to steady-state curve
![data-analysis-fig-2](https://montanamolecular.com/wp-content/uploads/2023/02/data-analysis-fig-2.jpg)
Rise to steady-state curve
Quantifying GPCR Signaling and Desensitization Kinetics
![arrestin-recycling](https://montanamolecular.com/wp-content/uploads/2023/02/arrestin-recycling-1.jpg)
Waveform data fitted to equations to quantify:
-
- Signal generation rate
- Desensitization rate
- Signal clearance rate
- Differences between GPCRs in signaling mechanisms and rates
![Oxytocin-&-M1-DAG](https://montanamolecular.com/wp-content/uploads/2023/02/Oxytocin-M1-DAG.jpg)