Montana Molecular News
Form and Function: consequences of subcellular cAMP signaling revealed
In a recent paper, Isabella Cattani-Cavalieri and her colleagues in Ren Ostrom’s laboratory found a new, powerful way to examine the functional consequences of different cAMP signalosomes (Cattani-Cavalieri et al., 2023). There has long been a suspicion that there are...
A breathtaking model for the cellular detection of hypoxia
In a recent paper, Peng and colleagues (Peng et al. 2023) use a variety of new approaches, and fresh ideas, to create a molecular model for how the cells of the carotid body sense the oxygen levels in our blood and use this to control our breathing. Surprisingly, key...
GPCR Summit 2022
Getting the most from your biosensor assays: Data analysis for GPCR discovery Join the DrGPCR Ecosystem today to attend this free workshop. Luciana Leo and Sam Hoare will show how you can use kinetic analysis to quantify the dynamics of GPCR signaling, arrestin...
Agilent BioTek Webinar: Biosensors for Cell Signaling
This webinar will highlight the technological tips and tricks to obtain high quality, high throughput kinetic data on BioTek plate readers, with biosensors for G-protein-coupled receptor second messengers and arrestin recruitment. It will also describe how to...
Differential Effects of GRK2 and GRK5 on Arrestin Recruitment Kinetics
Presented August 22nd at: The G Protein-coupled Receptor Kinases and Arrestins Conference: Key Modulators of Signal Transduction Although different GRK isoforms can enhance overall arrestin recruitment to specific GPCRs, the effect of each isoform on the kinetics of...
Environmental Impact of Basic Research
Greener Packaging Reducing the volume of plastics, styrofoam, and cardboard used in basic research can be a challenge, so we're taking steps to help. We switched the insulation in our packaging from styrofoam to biodegradable Green Cell...
Olfactory GPCRs Upregulated in Cancer
The Sweet Smell of a NobelThirty years ago, Linda Buck and Richard Axel described a large family of genes that encode what appeared to be G-protein coupled receptors, or GPCRs. These genes were expressed in the olfactory epithelium, and encoded an...
A Rapid and Sensitive Approach to Detecting SARS-CoV-2
There is a race in this pandemic to develop new technologies to detect SAR-CoV-2 virus and defeat its spread as quickly as possible. A bright light in this race recently appeared in a new paper published by Nanoscale Advances that describes a simple,...
Measuring partial and biased agonism at GPCRs on the FDSS/μCell
Kinetic analysis to measure agonist bias Montana Molecular’s genetically-encoded, fluorescent biosensors detect multiple receptor-mediated signaling pathways in real-time, live-cell assays. The kinetics of the responses for each signaling pathway can be used to...
The Neuroscience of Nausea
Nausea is a sense of malaise that all of us know. The sensation can be so overpowering that it leads us to wonder how and why this wretched condition happens
