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Montana Molecular News

 

Discovery On Target – Boston 2019

The latest developments in GPCR-Based Drug Discovery is coming to Discovery on Target in Boston this week! Learn about kinetic analysis and why monitoring GPCR signaling dynamics is so important. Quantify biased agonism reliably.  Meet Sam Hoare from Pharmechanics and...

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Targeting the Primary Cilium

Targeting the primary cilium The primary cilium is an incredibly fine process that protrudes from the apical surface of cells.  Most cells have a primary cilium, though it temporarily vanishes during mitosis.  For many years the primary cilia were largely neglected,...

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Lee Lab illuminates cAMP signaling in macrophages

The Lee Lab at University of Pennsylvania is a diverse group of cell biologists who combine their unique scientific perspectives to the better understanding of airway disease physiology and taste perception. In other words, this lab knows the nose and is enthusiastic...

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PIP2 biosensor used in new research on the regulation of cold sensitivity in DRG neurons.

In a bioRxiv preprint titled, “Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation”, graduate student Luyu Liu of Tibor Rohacs’ lab (rohacslab.org) at Rutgers Medical School and her colleagues explore how PIP2 levels, Ca2+, and the G-protein Gαq, converge to regulate activity of the cationic TRPM8 channel, which is normally activated by cold temperatures and chemical agonists such as menthol.

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Get a New Perspective on Gi Signaling

Robust Gi assay that, in real time, directly reports Gi mediated reductions in cAMP, across a variety of receptors and cell types on standard fluorescence plate readers or imaging systems. Simple, No cell lysis, No FRET, Single channel Can be targeted to...

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How to be a Beta Tester

New Arrestin Signaling, Targeted cAMP and Ca++ Assays Being a beta tester is a low cost way to get early access to the brightest new genetically-encoded fluorescent live cell assays. Take a sneak peek below at the sensors we're working on right...

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