Montana Molecular News

 

PIP2 biosensor used in new research on the regulation of cold sensitivity in DRG neurons.

In a bioRxiv preprint titled, “Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation”, graduate student Luyu Liu of Tibor Rohacs’ lab (rohacslab.org) at Rutgers Medical School and her colleagues explore how PIP2 levels, Ca2+, and the G-protein Gαq, converge to regulate activity of the cationic TRPM8 channel, which is normally activated by cold temperatures and chemical agonists such as menthol.

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Get a New Perspective on Gi Signaling

Robust Gi assay that, in real time, directly reports Gi mediated reductions in cAMP, across a variety of receptors and cell types on standard fluorescence plate readers or imaging systems. Simple, No cell lysis, No FRET, Single channel Can be targeted to...

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How to be a Beta Tester

New Arrestin Signaling, Targeted cAMP and Ca++ Assays Being a beta tester is a low cost way to get early access to the brightest new genetically-encoded fluorescent live cell assays. Take a sneak peek below at the sensors we're working on right now, and...

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Experimental Biology 2018

We're heading to Experimental Biology 2018 San Diego Convention Center April 21-25. Come visit us at Booth #1136. Tell us about your research and get $100 off any assay kit Our Posters:   Genetically-Encoded Fluorescent Assay to Detect Drug...

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BPS18 Biophysical Society Poster

New Fluorescent Tools to Identify Stressed Cells and Interrogated Second Messenger Signaling in Neurodegeneration. Meet us in San Francisco for the Biophysical Society 62nd Annual Meeting, February 17-21, 2018 Abstract Title: New Fluorescent...

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New Products to Launch at SLAS 2018

Montana Molecular to present new live cell assays for cell stress and toxicity and for screening phosphodiesterase inhibitors, sGC activators and stimulators. Visit with us at SLAS Monday, Feb 5th 5-6pm PDE specificity illuminated: Monitoring...

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New Fluorescent Tools to Monitor Cell Stress and Toxicity

This biosensor allows real-time monitoring of genetically or chemically induced cell stress and drug induced cellular toxicity in under 24 hours. It can be combined with second messenger biosensors to simultaneously monitor cell signaling in stressed and...

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Transgenic DAG Sensors

Check out this paper, just published in Cell Reports, about measuring DAG at the synapse in sensory neurons: Dynamics of Presynaptic Diacylglycerol in a Sensory Neuron Encode Differences between Past and Current Stimulus Intensity H. Ohno, N. Sakai, T. Adachi, Y, Iino...

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