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Diabetes Research

Gain insight into diabetes disease mechanisms and GLP-1 receptor pharmacology with bright fluorescent biosensor assays. Examine Biased agonism at the GLP-1 receptor in cell models and GPCR second messenger signaling in pancreatic islet cells.

GPCR Signaling in Diabetes

Monitor GPCR second messenger signaling kinetics with live-cell, fluorescent GPCR assays. Green and red fluorescent biosensor assays can be combined to detect simultaneous signaling in the same cells or wells. Co-transduce GPCRs like the GLP-1 receptor (#Z0600N) in cell models of diabetes. Monitor bright fluorescent assay signals on automated plate readers or imaging systems.


Dose-dependent cAMP responses in HEK293 cells co-expressing GLP-1 receptor.

Expression in Pancreatic Islet Cells

Use assay-ready BacMam vectors to express fluorescent biosensors in pancreatic islets and image signaling kinetics. Target expression to specific cell sub-populations with custom promoters.

Read about research utilizing our assays in pancreatic islet cells:

Mouse Pancreatic Islets

Human Pancreatic Islets

Mouse α-Cells

Alternate viral vectors (AV, Lentivirus, AAV) are available by special order as well.


BacMam-mediated cADDis cAMP Sensor expression in a pancreatic islet. Shigeto, et al. 2016.

GLP1-R Biased Agonism

Fluorescent Green β-arrestin-GLP-1 kits are now available! Use cADDis cAMP, DAG, and arrestin assays to examine biased agonism at the GLP-1 receptor in cell models.

β-Arrestin GLP-1 kits include the Green β-arrestin sensor, GLP-1R, and GRK 5 packaged in BacMam.

GLP-1 Exendin-4 Kinetic dose-response data collected by the Green Arrestin sensor in HEK 293T cells.

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Contact Us

If you have any questions about using these tools in your cells or would like to request a quote, send us an email at We’re happy to help!