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Reversible Ratiometric Cellular Stress & Toxicity Detection

Cells can become stressed by exposure to protein products from mutant alleles or toxic chemicals. Cell stress triggers cytosolic splicing of XBP1, which in turn produces bright green fluorescence.  Because the fluorescent signal is reversible, the assay can be used to screen for toxic effects of drugs or for drugs that return the cell to a healthy state. This sensor can be combined with a red sensor to study signaling in stressed vs healthy cells.

  • A robust, reversible biosensor for ER-stress and the UPR.
  • Ideal for use in primary cultures or iPSC-derived neurons or cardioimyocytes.
  • Combine with a red cADDis, GECO Ca2+, or DAG sensor to simultaneously monitor second messenger signaling.
  • Monitor fluorescence changes on an automated plate reader or imaging system. 
  • Faster and more sensitive than counting dead cells.
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Detect Cell Stress in Living Cells