Scientific Publications

• Chen, X., et. al. Phenylephrine, a common cold remedy active ingredient, suppresses uterine contractions through cAMP signalling. Scientific Reports Aug. 2018.
• N. H. Wray, J.M. Schappi, H. Singh, N.D. Senese, and M.M. Rasenick. NMDAR-independent, cAMP-dependent antidepressant actions of ketamine. Molecular Psychiatry. April 2, 2018.
• T. Buranda, et. al. A High-Throughput Flow Cytometry Screen Identifies Molecules that Inhibit Hantavirus Cell Entry. SLAS Discovery. April 2, 2018.
• H. Zou, M. Schmidt, and R. Gosens PDE8: A Novel Target in Airway Smooth Muscle. American Journal of Respiratory Cell and Molecular Biology. Vol. 58, No. 4. April 01 2018
• T.B. Johnstone, et al. PDE8 is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β₂AR-AC6. American Journal of Respiratory Cell and Molecular Biology. Dec. 2017
• Tatsuru Togo, Cell membrane disruption stimulates cAMP and Ca2+ signaling to potentiate cell membrane resealing in neighboring cells. Biology Open. bio.028977 doi: 10.1242/bio.028977 Published 1 November 2017
•  McCrink KA, Maning J, Vu A, Jafferjee M, Marrero C, Brill A, Bathgate-Siryk A, Dabul S, Koch WJ, Lymperopoulos A. β-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco(endo)plasmic Reticulum Ca2+-ATPase-Dependent Positive Inotropy in Cardiomyocytes. Hypertension. 2017 Nov; 70: 972-981. Link to Supplemental Data
• Q. Wang, A. N. Pronin, K. Levay, J. Almaça, A. Fornoni, A. Caicedo, V. Z. Slepak. Regulator of G protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion. FASEB J. 2017 Jul 7, fj.201700197RR.
• J. Almaça, J. Molina, D. Menegaz, A.N. Pronin, A. Tamayo, V. Slepak, P. Berggren, A. Caicedo.  Human beta cells produce and release serotonin to inhibit glucagon secretion from alpha cells.Cell Reports, Volume 17, Issue 12, p3281–3291, 2016.
• Moore, B.S., Stepanchick, A.N., Tewson, P.H., Hartle, C.M., Zhang, J., Quinn, A.M., Hughes, T.E., Mirshahi, T. Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics. PNAS 2016.
• Tewson, P., Martinka, S., Shaner, N.C., Hughes, T., Quinn, A.M. New DAG and cAMP Sensors Optimized for Live-Cell Assays in Automated Laboratories. J Biomol Screen 1087057115618608, first published on December 11, 2015 as doi:10.1177/1087057115618608
• H. Ohno, N. Sakai, T. Adachi, Y. Iino. Dynamics of Presynaptic Diacylglycerol in a Sensory Neuron Encode Differences between Past and Current Stimulus Intensity.Cell Reports. Sept. 2017. Vol. 20, Issue 10, p2294-2303.
•  Shigeto, M., Ramracheya, R., Tarasov, A.I., et al. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. J Clin Invest. 2015. doi:10.1172/JCI81975.
• Arttamangkul, S., Birdsong, W., Williams, J.T. Does PKC activation increase the homologous desensitization of μ opioid receptor? British Journal of Pharmacology. 2015 Jan;172(2):583-92. doi: 10.1111/bph.12712. Epub 2014 Jul 1.
• Xingjuan, C., Egly, C., Riley, A.M., Li, W.,Tewson, P., Hughes, T.E., Quinn, A.M., Obukhov, A.G. PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity. Cells. 2014, 3(2), 247-257.
• Tewson, P.H., Quinn, A.M., and Hughes, T.E. (2013). A multiplexed fluorescent assay for independent second-messenger systems: decoding GPCR activation in living cells. Journal of Biomolecular Screening 18, 797–806.
• Tewson, P., Westenberg, M., Zhao, Y., Campbell, R., Quinn, A.M., Hughes, T.E. Simultaneous Detection of Ca2+ and Diacylglycerol Signaling in Living Cells. PLoS One. 2012;7(8):e42791. doi: 10.1371/journal.pone.0042791. Epub 2012 Aug 17.
• Cañizal M.C., Winkler C., Ziegler N., Hoffman, C. A Dual Ca²⁺/ DAG Sensor Reports on Ligand Efficiency
• P. Tewson, S. Martinka, S. Tillo, T. Hughes, A.M. Quinn, C. Peters (2016). Simultaneous detection of GPCR second messengers in living cells. BMG Application Note
• Alford, S.C., Abdelfattah, A.S., Ding, Y., and Campbell, R.E. (2012). A fluorogenic red fluorescent protein heterodimer.Chem. Biol. 19, 353–360.
• Tewson, P.H., Quinn, A.M., and Hughes, T.E. PCT Application No. PCT/US13/3188 Entitled, Genetically Encoded Fluorescent Sensors for Intracellular Signaling Through Diacylglycerol Pathways.
• Ding, Y., Li, J., Enterina, J.R., Shen,Y., Zhang, I.,Tewson, P.H., Mo, G.C.H., Zhang, J., Quinn, A.M., Hughes, T.E., Maysinger, D., Alford, S.C., Zhang, Y., Campbell, R.E. (2015) Ratiometric biosensors based on dimerization dependent fluorescent protein exchange.Nature Methods, doi:10.1038/nmeth.3261
• Tewson, P., Westenberg, M., Zhao, Y., Campbell, R., Quinn, A.M., Hughes, T.E. Simultaneous Detection of Ca²⁺and Diacylglycerol Signaling in Living Cells. PLoS One. 2012.
• Tewson, P.H., Quinn, A.M., and Hughes, T.E. (2013). A multiplexed fluorescent assay for independent second-messenger systems: decoding GPCR activation in living cells. Journal of Biomolecular Screening 18, 797–806.
• Wu, J., Liu, L., Matsuda, T., Zhao, Y., Rebane, A., Drobizhev, M., Chang, Y., Araki, S., Arai, Y., March, K., Hughes, T.E., Sagou, K., Miyata, T., Nagai, T., Li, W., Campbell, R.E. Improved Orange and Red Ca²⁺Indicators and Photophysical Considerations for Optogenetic Applications. ACS Chem Neurosci. 2013 Jun 19.
• Carlson, H.J., Campbell, R.E. Mutational Analysis of a Red Fluorescent Protein-Based Calcium Ion Indicator. Sensors, 2013.

• J. Quinn, P. Tewson, S. Martinka, K. Harlen, T. Hughes, A.M. Quinn. PDE Specificity Illuminated: Monitoring cGMP and cAMP Levels inLiving Cells. SLAS 2018 Poster

• K. Harlen, J. Quinn, T. Hughes, A.M. Quinn. New Fluorescent Tools to Monitor Cell Stress and Toxicity. SLAS 2018 Poster

• T. Hughes, S. Martinka, P. Tewson,  S. Tillo, R. Kettnhofen, A.M. Quinn. Measuring Signal Transduction in Axiogenesis Cardiomyocytes.  Poster

• Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. & Mori, K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.Cell 107, 881–891 (2001).