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GPCRs in BacMam

Express GPCRs in mammalian cells

  • Unmodified, untagged, human GPCRs
  • Packaged in BacMam for consistent, titratable expression in most mammalian cell types – including cell lines, iPSCs, and primary cultures
  • Easily co-express with biosensors for GPCR signaling
  • Custom viruses, including splice or species variants, cell-specific promoters, genetic tags, and more are available on request

GPCR Catalog

Ready-to-ship kits
Full List

#Z0100N: Human D1 Dopamine Receptor (DRD1)
#Z0110N: Human D2 Dopamine Receptor (DRD2)
#Z0120N: Human D3 Dopamine Receptor (DRD3)
#Z0200N: Human M1 Muscarinic Receptor (CHRM1)
#Z0200G: Human M1 Muscarinic Receptor (CHRM1) – Green
#Z0200R: Human M1 Muscarinic Receptor (CHRM1) – Red
#Z0210N: Human M2 Muscarinic Receptor (CHRM2)
#Z0220N: Human M3 Muscarinic Receptor (CHRM3)
#Z0300N: Human A1 Adenosine Receptor (ADORA1)
#Z0400N: Human Succinate Receptor (SUCNR1)
#Z0500N: Human β2 Adrenergic Receptor (ADRB2)
#Z0500G: Human β2 Adrenergic Receptor (ADRB2) – Green
#Z0500R: Human β2 Adrenergic Receptor (ADRB2) – Red
#Z0600N: Human GLP-1 Receptor (GLP1R)
#Z0610N: Human Calcitonin Receptor (CALCR)
#Z0620N: Human Vasopressin Receptor (AVPR2)
#Z0700N:Human Nociceptin Opioid Receptor (OPRX)
#Z0710N: Human Kappa Opioid Receptor (OPRK1)
#Z0720N:Human Mu Opioid receptor (OPRM1)
#Z0730N: Human Cannabinoid Receptor Type 1 (CNR1)
#Z0740N: Human Delta Opioid Receptor (OPRD1)
#Z0800N: Human Angiotensin II Type I Receptor (AGTR1)
#Z0900N: Human Oxytocin Receptor (OXTR)
#Z1000N: Human C-X-C Chemokine Receptor Type 4 (CXCR4)
#Z1100N: Human Serotonin 5HT2A Receptor (HTR2A)
#Z1200N: Human Proteinase-Activated 2 Receptor (PAR2-F2RL1)
#Z1300N: Human Lysophosphatidic Acid 1 Receptor (LPAR1)
#Z1400N: Human Parathyroid Hormone 1 Receptor (PTH1R)
#Z1500N: Human Serotonin 5-HT1A Receptor (HTR1A)
#Z1600N: Human Gastric Inhibitory Polypeptide Receptor (GIPR)
#Z1700N: Human Cannabinoid Receptor Type 2 (CNR2)
#Z1800N: Human Serotonin 5HT2C Receptor (HTR2C)
#Z1900N: Human Serotonin 5-HT1B  Receptor (HTR1B)
#Z2000N: Human Glucagon Receptor (GCGR)
#Z2100N: Human Somatostatin Receptor Type 2 (SSTR2)

Simple Protocol

  • No cell lysis
  • BSL-1 Vector
  • Minimal Liquid Handling
  • Low Toxicity
  • Batch-transduce and freeze cells
  • Benefits of Using BacMam

Don’t see your receptor of interest?

Your GPCR of interest isn’t listed? Or you have a specific modification in mind? We offer custom BacMam preparations and are more than happy to discuss your project with you. Send an email to

Some common requests include:

  • Alternative species and splice variants
  • Constitutively expressed fluorescent proteins or genetic tags on GPCRs
  • Cell-specific promoters or Cre-inducible systems to target cellular subpopulations
Montana Paintbrush RFP expressed in HEK293 cells

BacMam-packaged Montana Paintbrush expressing in HEK293 cells, showing even, consistent expression.

Pair with a GPCR Signaling Assay

To look at receptor signaling, our GPCR second messenger sensors for cAMP, DAG, PIP2, Calcium, and arrestin can easily be co-transduced along with your receptor.

More information on our Gs, Gi, and Gq signaling assays can be found on our GPCR Biology page, and some example data is shown below.



Figure showing Gs-mediated cAMP signaling from GLP-1R activation

Co-expression of cAMP sensor and GLP1 receptor (#Z0600N)

Figure showing Gi mediated Mu Opioid cAMP signaling

Co-expression of cAMP sensor and Mu Opioid receptor (#Z0720N)

Figure showing pharmacological data gathered from DAG kinetic signaling

Co-expression of DAG sensor and either M1 (#Z0200N) or Oxytocin (#Z0900N) receptors

Figure showing dose-dependent arrestin recruitment at the glucagon receptor

Co-expression of Arrestin sensor and Glucagon receptor (#Z2000N)