GPCR Signaling Kinetics
Data Analysis
Time course equations for a variety of curve shapes entered into GraphPad Prism as a plug-in.
Parameters include:
-
- Â Initial rate of signal generation
- Fade (desensitization) rate
- Steady-State signal level
- Peak level and peak time
References
Rise and fall to steady-state curve
Rise to steady-state curve
Quantifying GPCR Signaling and Desensitization Kinetics
Waveform data fitted to equations to quantify:
-
- Signal generation rate
- Desensitization rate
- Signal clearance rate
- Differences between GPCRs in signaling mechanisms and rates
Products
GPCRs in BacMam Virus
Targeted GECO Ca2+
mNeonGreen BacMam Tools
Mitochondrial Calcium Sensor
Product U0652G
Nuclear-Targeted cADDis cAMP Assays
Products U0221R & D0221G
Endoplasmic Reticulum Calcium Sensor
Product U0654G
GiantinPaint mNeonGreen Golgi Label
Product P1040G
Mitochondrial Labels
Product P1010G
MitoPaint COX8
Membrane Targeted AKAP cADDis cAMP Assays
Products U0261G , U0262G, U0267G, U0266G
Membrane-Targeted cADDis cAMP Assays
Products U0241R, D0241G, U0267G, D0231G
Membrane-Targeted DAG Assays
Product D0331G
CAAX
