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Express RAMPs with BacMam

Express RAMPs with BacMam

Express RAMPs with BacMam BacMam-packaged RAMP1, RAMP2, and RAMP3 are now available from Montana Molecular! Receptor Activity-Modifying Proteins (RAMPs) can regulate the function and specificity of G-protein-coupled receptors – influencing their trafficking,...
Introducing Big Sky BacMam

Introducing Big Sky BacMam

Introducing Big Sky BacMam The R&D team at Montana Molecular has been hard at work improving our BacMam vector! We’re excited to release Big Sky BacMam – a vector which, in our hands, yields greatly improved transduction efficiency in HEK and CHO...
Detecting inhibitors of mutant 3CL proteases

Detecting inhibitors of mutant 3CL proteases

Find your next-generation SARS-CoV-2 inhibitor using mutant 3CL proteases The SARS-CoV-2 protease is crucial to virus replication. If the main protease, known as 3CLpro can be blocked, the virus can be stopped. The commonly prescribed Paxlovid contains a 3CLpro...
Montana Paintbrush

Montana Paintbrush

Montana Paintbrush Montana Paintbrush (Paintbrush, MT Paintbrush) is a bright, rapidly folding red fluorescent protein developed at Montana Molecular. It is nearly twice as bright as mCherry 24 hours after transduction as seen in Figure 1 below. Figure 1: Fluorescence...
Next-generation drugs for the evolving SARS-CoV-2 virus

Next-generation drugs for the evolving SARS-CoV-2 virus

Next-generation drugs for the evolving SARS-CoV-2 virus There is increasing evidence that new variants of SARS-CoV-2 are appearing that cannot be treated with Paxlovid.  This means that the next generation of antivirals will soon be needed to reduce the severity of...
New AKAP-targeted cADDis cAMP Sensors

New AKAP-targeted cADDis cAMP Sensors

New AKAP-targeted cADDis Sensors Most cAMP measurements are global measurements of total cellular cAMP. However when biosensors are targeted to different subcellular domains, they often reveal more nuanced views of very localized cAMP signaling. There are many...