Fluorescent Detection of Cellular Stress & Toxicity
The cell stress sensor is a genetically-encoded fluorescent biosensor that produces very bright fluorescence when the cell endures endoplasmic reticulum (ER) stress or undergoes the unfolded protein response (UPR). A broad host of both chemical compounds and genetic mutations can induce ER stress. The UPR is one of the major stress pathways within the cell, which allows the stress sensor to detect a wide range of stress inducing stimuli, some whose primary target is not the ER.
Cell Stress BacMam Kits
US & Canada Prices∗:
10 mL … $595
30 mL … $1195
60 mL … $1795
∗Outside the US & Canada? Please check with regional distributors for local pricing.
Plate Reader or Microscope Compatible
Bright Green Fluorescence Response
Detect a wide range of cell stress
including ER and UPR
Protocols can be found in our main menu across the top of the page or by clicking the link below:
• Yoshida, H., Matsui, T., Yamamoto, A., Okada, T. & Mori, K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107, 881–891 (2001).
In your Cell Stress Sensor Kit:
- 10, 30, or 60 mL of Sensor
- HDAC Inhibitor (Sodium Butyrate)
- Thapsigargin (positive control)