Activating a signaling pathway with light is one of the brightest ideas to come along. Pietro de Camilli’s and Bertil Hille’s labs collaborated on a brilliant example of this illuminating technique! Optogenetic control of phosphoinositide metabolism describes a reversible controller for PIP2 and PIP3 signaling with unprecedented spatial–temporal resolution. A shiny new tool shedding light on the biology of signal transduction.
