TMPRSS2 in BacMam for controlled expression in live mammalian cells and increased Spike binding

TMPRSS2 in BacMam for controlled expression in live mammalian cells and increased Spike binding
Baculovirus pseudotyped with SARS-CoV-2 Spike protein variant with D614G, E484K, N501Y, K417N mutations. A pseudovirus that will produce red fluorescent nuclei upon successful entry, into host cells expressing ACE2
Baculovirus pseudotyped with SARS-CoV-2 Spike protein variant with D614G, E484K, N501Y, K417N mutations. A pseudovirus that will produce green fluorescent nuclei upon successful entry, into host cells expressing ACE2
Baculovirus pseudotyped with SARS-CoV-2 Spike protein variant with D614G, E484K, N501Y, K417T mutations. A pseudovirus that will produce green fluorescent nuclei upon successful entry, into host cells expressing ACE2
Host Cell Factors for SARS-CoV-2 Viral Entry Host Factors for Viral Entry Spike protein on SARS-CoV-2 interacts with the ACE2 receptor on the host cell to initiate viral entry, but other host factors are also involved. While ACE2 is necessary, it does not appear to...
Overview of SARS-CoV-2 Viral Entry The generally accepted model for SARS-CoV-2 viral entry involves two crucial elements: the Spike protein on the surface of the enveloped virus, and the host receptor ACE2. The Spike protein has a high...
Thank you for your interest in Montana Molecular’s assays for SARS-CoV-2 research and drug discovery. In a rapidly evolving field, as new insights into the mechanisms of viral entry come to light, we sincerely appreciate your patience and feedback as we continue to...