Biased Agonism in Slow Motion: Mapping the 12-Hour Evolution of PTH1R cAMP Signaling and Arrestin Recruitment
Using cADDis (cAMP) and Borealis (Arrestin) biosensors we are now able to map the signaling profiles of three distinct PTH1 receptor agonists over a continuous 12-hour window. The results redefine how we understand PTH1R ligand behavior. Sustained vs. Transient cAMP...
Calcitonin family receptor cAMP assays
Create full amylin pharmacology profiles using cAMP assays and titratable receptor components (CTR and RAMPs) BacMam-packaged calcitonin receptor (CTR) and RAMP1–3 enable expression of functional amylin receptor subtypes (AMY1–3) in mammalian cells. BacMam provides...
Phosphorylation of key serines in the GLP-1R receptor C-terminus – an interesting tail
The GLP-1R receptor is currently a hot topic, both in pharmacology and in the popular news of the day. Understanding how this crucial receptor works at the molecular level is important in many regards, and the recent preprint from Manchanda and colleagues (Manchanda...
Society for Neuroscience 2025
Download Montana Molecular posters from SfN 2025 Download the Poster ? Next Generation Viruses to Interrogate iPSC-derived Neurons and Microglia Traditional viral vectors, adeno-associated virus (AAV) and lentivirus, have a minimal cargo capacity. On...