Detecting inhibitors of mutant 3CL proteases
Find your next-generation SARS-CoV-2 inhibitor using mutant 3CL proteases The SARS-CoV-2 protease is crucial to virus replication. If the main protease, known as 3CLpro can be blocked, the virus can be stopped. The commonly prescribed Paxlovid contains a 3CLpro...
Next-generation drugs for the evolving SARS-CoV-2 virus
Next-generation drugs for the evolving SARS-CoV-2 virus There is increasing evidence that new variants of SARS-CoV-2 are appearing that cannot be treated with Paxlovid. This means that the next generation of antivirals will soon be needed to reduce the severity of...
New AKAP-targeted cADDis cAMP Sensors
New AKAP-targeted cADDis Sensors Most cAMP measurements are global measurements of total cellular cAMP. However when biosensors are targeted to different subcellular domains, they often reveal more nuanced views of very localized cAMP signaling. There are many...
Form and Function: consequences of subcellular cAMP signaling revealed
Form and Function Consequences of subcellular cAMP signaling revealed In a recent paper, Isabella Cattani-Cavalieri and her colleagues in Ren Ostrom’s laboratory found a new, powerful way to examine the functional consequences of different cAMP signalsomes...
