Functional Cell-based Assays Verified & Compound Libraries
This unique platform is a powerful resource for researchers developing 3CLpro inhibitors and can streamline the development of safe and effective therapeutic treatments for COVID-19.
OTAVAchemicals and Montana Molecular have a complete solution for COVID-19 drug discovery that combines verified compound libraries with functional cell-based assays and drug development services.
The assay is 3CLglow, a live cell, fluorescent biosensor that reports target engagement and physiologically-relevant measurements of IC50 in living cells.
The OTAVA SARS-CoV-2 Main Protease Targeted Library contains 1017 compounds with predicted activity against SARS-CoV-2 3CL protease. The library has been designed with receptor-based virtual screening using crystal structure (PDB ID: 6LU7) of SARS-CoV-2 main protease. The structure of the enzyme active site was used to select compounds based on docking scores and intermolecular hydrogen bonds between key amino acid residues and the compound.