Montana Molecular News
Dogs are people too!
At Montana Molecular the dogs are part of the team. Our 4 legged colleagues bring energy, personality, and a little bit of fun to our workdays. Around here, we don’t just study living systems—we celebrate them.
Biased Agonism in Slow Motion: Mapping the 12-Hour Evolution of PTH1R cAMP Signaling and Arrestin Recruitment
Using cADDis (cAMP) and Borealis (Arrestin) biosensors we are now able to map the signaling profiles of three distinct PTH1 receptor agonists over a continuous 12-hour window. The results redefine how we understand PTH1R ligand behavior.Sustained vs. Transient cAMP...
Calcitonin family receptor cAMP assays
Create full amylin pharmacology profiles using cAMP assays and titratable receptor components (CTR and RAMPs)BacMam-packaged calcitonin receptor (CTR) and RAMP1–3 enable expression of functional amylin receptor subtypes (AMY1–3) in mammalian cells. BacMam provides...
Phosphorylation of key serines in the GLP-1R receptor C-terminus – an interesting tail
The GLP-1R receptor is currently a hot topic, both in pharmacology and in the popular news of the day. Understanding how this crucial receptor works at the molecular level is important in many regards, and the recent preprint from Manchanda and colleagues (Manchanda...
Society for Neuroscience 2025
Download Montana Molecular posters from SfN 2025 Traditional viral vectors, adeno-associated virus (AAV) and lentivirus, have a minimal cargo capacity. On the other hand, BacMam, a double stranded DNA insect virus, can carry up to 38 kilobases. This...
NIH Supports Biosensor Development for GPCRs in Cancer
Bozeman, MT 9/30/3025 - Montana Molecular is celebrating the start of a new award from the National Cancer Institute at the National Institutes of Health. The company, based in Bozeman, Montana, is using a machine learning approach to design the structure of a...
Summer Days
Summer days: long hikes, water sports, hot dogs, fresh peaches, and plenty of sunscreen. How is it that our skin changes when exposed to sun, and why is it that those hot dogs on the grill smell so good? Two recent papers provide new glimpses of the molecular...
Montana Molecular Welcomes Chris Johnson as Senior Director of Operations
FOR IMMEDIATE RELEASE BOZEMAN, MT June 18, 2025 -- Montana Molecular, a biopharma company with a history of innovation in designing novel fluorescent biosensors and gene delivery tools for drug discovery and cell biology research, is pleased to announce that Dr...
Psychedelic Drug Actions at Serotonin Receptors and the Path Towards Safer Treatments for Mental Disorders
How can we capture the therapeutic potential that psychedelic drugs have demonstrated against mental disorders while fading their risks in the discovery of new medicines? A key insight highlighted using fluorescent biosensors is that non-hallucinogenic...
Big Sky BacMam Improves Transduction Efficiency
Big Sky BacMam is an improvement on Montana Molecular's original "OG" BacMam vector. In our first experiments with HEK293T and CHO-K1 cells, we found Big Sky BacMam yielded significant boosts in expression. Montana Molecular's R&D team and users of our fluorescent...
