Montana Molecular News
Discovery On Target – Boston 2019
The latest developments in GPCR-Based Drug Discovery is coming to Discovery on Target in Boston this week! Learn about kinetic analysis and why monitoring GPCR signaling dynamics is so important. Quantify biased agonism reliably. Meet Sam Hoare from Pharmechanics and...
Expression and Analysis of Neurodegenerative Associated Proteins
Express your neurodegenerative-associated protein of interest with bright fluorescent biosensors for cell stress and signaling in your favorite neuronal culture or cell line. ”Live-cell assays for cell stress responses reveal new patterns of cell signaling” Identify...
Targeting the Primary Cilium
Targeting the primary cilium The primary cilium is an incredibly fine process that protrudes from the apical surface of cells. Most cells have a primary cilium, though it temporarily vanishes during mitosis. For many years the primary cilia were largely neglected,...
SLAS 2019
Lee Lab illuminates cAMP signaling in macrophages
The Lee Lab at University of Pennsylvania is a diverse group of cell biologists who combine their unique scientific perspectives to the better understanding of airway disease physiology and taste perception. In other words, this lab knows the nose and is enthusiastic...
MT Molecular at ASCB 2018
Don’t miss our Microsymposium & Posters at ASCB 2018 meeting!
PIP2 biosensor used in new research on the regulation of cold sensitivity in DRG neurons.
In a bioRxiv preprint titled, “Gαq sensitizes TRPM8 to inhibition by PI(4,5)P2 depletion upon receptor activation”, graduate student Luyu Liu of Tibor Rohacs’ lab (rohacslab.org) at Rutgers Medical School and her colleagues explore how PIP2 levels, Ca2+, and the G-protein Gαq, converge to regulate activity of the cationic TRPM8 channel, which is normally activated by cold temperatures and chemical agonists such as menthol.
Get a New Perspective on Gi Signaling
Robust Gi assay that, in real time, directly reports Gi mediated reductions in cAMP, across a variety of receptors and cell types on standard fluorescence plate readers or imaging systems. Simple, No cell lysis, No FRET, Single channel Can be targeted to...
How to be a Beta Tester
New Arrestin Signaling, Targeted cAMP and Ca++ Assays Being a beta tester is a low cost way to get early access to the brightest new genetically-encoded fluorescent live cell assays. Take a sneak peek below at the sensors we're working on right...
Live Cell Assay Movies
See Montana Molecular's live cell assays in action
