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Measuring partial and biased agonism at GPCRs on the FDSS/μCell

Measuring partial and biased agonism at GPCRs on the FDSS/μCell

Measuring partial and biased agonism at GPCRs on the FDSS/μCell Kinetic analysis to measure agonist bias Montana Molecular’s genetically-encoded, fluorescent biosensors detect multiple receptor-mediated signaling pathways in real-time, live-cell assays. The kinetics...
The Neuroscience of Nausea

The Neuroscience of Nausea

The Neuroscience of Nausea The elusive area postrema  Nausea is a sense of malaise that all of us know. The sensation can be so overpowering that it leads us to wonder how and why this wretched condition  happens. Researchers in Stephen Liberles’ lab at Harvard...
SARS-CoV-2 Variant Pseudoviruses

SARS-CoV-2 Variant Pseudoviruses

At Montana Molecular, we are committed to developing validated tools and services to support COVID-19 drug discovery. 2nd generation pseudoviruses for SARS-CoV-2 variants are on the way. Emerging SARS CoV-2 VariantsIn the spring of 2020, Manaus Brazil, was hit hard by...
Covid 19 Drug Discovery Services

Covid 19 Drug Discovery Services

Functional Cell-based Assays Verified & Compound Libraries  This unique platform is a powerful resource for researchers developing 3CLpro inhibitors and can streamline the development of safe and effective therapeutic treatments for COVID-19. OTAVAchemicals and...
Mpro inhibitor saves cats from certain death

Mpro inhibitor saves cats from certain death

Feline Infectious Peritonitis (FIP) is caused by a coronavirus. The 3CLpro of this virus is much like the one in SARS-CoV-2 and is crucial for viral replication. In 2016, Kim and colleagues showed that the compound GC376 blocked viral replication in cats destined to...
SARS-CoV-2 Neutralization Assay

SARS-CoV-2 Neutralization Assay

Identify neutralizing antibodies that inhibit SARS-CoV-2 host cell entry Montana Molecular’s SARS-CoV-2 pseudovirus neutralization assays provide safe and cost effective solutions for testing the effects of Spike antibodies in live cells. Pseudo-SARS-CoV-2 is a BSL-1...