New AKAP-targeted cADDis cAMP Sensors
New AKAP-targeted cADDis Sensors Most cAMP measurements are global measurements of total cellular cAMP. However when biosensors are targeted to different subcellular domains, they often reveal more nuanced views of very localized cAMP signaling. There are many...
Form and Function: consequences of subcellular cAMP signaling revealed
Form and Function Consequences of subcellular cAMP signaling revealed In a recent paper, Isabella Cattani-Cavalieri and her colleagues in Ren Ostrom’s laboratory found a new, powerful way to examine the functional consequences of different cAMP signalsomes...
A breathtaking model for the cellular detection of hypoxia
In a recent paper, Peng and colleagues (Peng et al. 2023) use a variety of new approaches, and fresh ideas, to create a molecular model for how the cells of the carotid body sense the oxygen levels in our blood and use this to control our breathing. Surprisingly, key...
GPCR Summit 2022
Getting the most from your biosensor assays: Data analysis for GPCR discovery Join the DrGPCR Ecosystem today to attend this free workshop. Luciana Leo and Sam Hoare will show how you can use kinetic analysis to quantify the dynamics of GPCR signaling, arrestin...