Next-generation drugs for the evolving SARS-CoV-2 virus
Next-generation drugs for the evolving SARS-CoV-2 virus There is increasing evidence that new variants of SARS-CoV-2 are appearing that cannot be treated with Paxlovid. This means that the next generation of antivirals will soon be needed to reduce the severity of...
New AKAP-targeted cADDis cAMP Sensors
New AKAP-targeted cADDis Sensors Most cAMP measurements are global measurements of total cellular cAMP. However when biosensors are targeted to different subcellular domains, they often reveal more nuanced views of very localized cAMP signaling. There are many...
Form and Function: consequences of subcellular cAMP signaling revealed
Form and Function Consequences of subcellular cAMP signaling revealed In a recent paper, Isabella Cattani-Cavalieri and her colleagues in Ren Ostrom’s laboratory found a new, powerful way to examine the functional consequences of different cAMP signalsomes...
A breathtaking model for the cellular detection of hypoxia
In a recent paper, Peng and colleagues (Peng et al. 2023) use a variety of new approaches, and fresh ideas, to create a molecular model for how the cells of the carotid body sense the oxygen levels in our blood and use this to control our breathing. Surprisingly, key...