Montana Molecular News
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Detecting inhibitors of mutant 3CL proteases
Find your next-generation SARS-CoV-2 inhibitor using mutant 3CL proteasesThe SARS-CoV-2 protease is crucial to virus replication. If the main protease, known as 3CLpro can be blocked, the virus can be stopped. The commonly prescribed Paxlovid contains a 3CLpro...
Next-generation drugs for the evolving SARS-CoV-2 virus
Next-generation drugs for the evolving SARS-CoV-2 virusThere is increasing evidence that new variants of SARS-CoV-2 are appearing that cannot be treated with Paxlovid. This means that the next generation of antivirals will soon be needed to reduce the severity of...
New AKAP-targeted cADDis cAMP Sensors
New AKAP-targeted cADDis SensorsMost cAMP measurements are global measurements of total cellular cAMP. However when biosensors are targeted to different subcellular domains, they often reveal more nuanced views of very localized cAMP signaling. There are many...
Form and Function: consequences of subcellular cAMP signaling revealed
In a recent paper, Isabella Cattani-Cavalieri and her colleagues in Ren Ostrom’s laboratory found a new, powerful way to examine the functional consequences of different cAMP signalsomes (Cattani-Cavalieri et al., 2023). There has long been a suspicion that there are...
A breathtaking model for the cellular detection of hypoxia
In a recent paper, Peng and colleagues (Peng et al. 2023) use a variety of new approaches, and fresh ideas, to create a molecular model for how the cells of the carotid body sense the oxygen levels in our blood and use this to control our breathing. Surprisingly, key...
GPCR Summit 2022
Getting the most from your biosensor assays: Data analysis for GPCR discovery Join the DrGPCR Ecosystem today to attend this free workshop. Luciana Leo and Sam Hoare will show how you can use kinetic analysis to quantify the dynamics of GPCR signaling, arrestin...
Agilent BioTek Webinar: Biosensors for Cell Signaling
This webinar will highlight the technological tips and tricks to obtain high quality, high throughput kinetic data on BioTek plate readers, with biosensors for G-protein-coupled receptor second messengers and arrestin recruitment. It will also describe how to...
Differential Effects of GRK2 and GRK5 on Arrestin Recruitment Kinetics
Presented August 22nd at: The G Protein-coupled Receptor Kinases and Arrestins Conference: Key Modulators of Signal Transduction Although different GRK isoforms can enhance overall arrestin recruitment to specific GPCRs, the effect of each isoform on the kinetics of...
Environmental Impact of Basic Research
Greener Packaging Reducing the volume of plastics, styrofoam, and cardboard used in basic research can be a challenge, so we're taking steps to help. We switched the insulation in our packaging from styrofoam to biodegradable Green Cell...
