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#C1161G 3CLglowUp Assay Kit


A bright, fluorescent live cell assay for SARS-CoV-2 3CLpro enzyme inhibition and activity.



SARS-CoV-2 assays and reagents

3CLglowUp 3CLpro (Mpro) Inhibition Assay

The 3CLglowUp Assay kit is our newest and brightest tool for screening 3CL protease inhibitors. The kit includes 2 BacMam viruses. One expresses the 3CLpro enzyme, the other expresses a green fluorescent biosensor for 3CLpro enzyme activity (3CLglowUp). The 3CLglowUp sensor increases in fluorescence in response to inhibition of the 3CLpro enzyme.

  • Identify protease inhibitors that target SARS-CoV-2 replication
  • Cost effective screening with minimal safety requirements (BSL-1)
  • Test new protease inhibitors with our suite of 3CL proteases with mutations that decrease efficacy of existing therapeutics like Nirmatrelvir

Materials in the Kit:

• Green Fluorescent 3CLpro reporter in BacMam (3CLglowUp BacMam)

• 3CLpro Enzyme in BacMam

• Sodium Butyrate, 500 mM in H2O


Additional information


We strive for prompt delivery of each order, so we ship by FedEx 2-day service in lightweight, sturdy, and reusable/biodegradable packaging with an insulated cooler and moisture-resistant refrigerant gel packs. Shipping days are Mon-Wed so product does not sit in transit over the weekend. Web store ships to US & Canada only, contact sales for other locations.

Protocol for Use


Kit Volume

5mL, 30mL, 60mL

More Info