New AKAP-targeted cADDis Sensors
Most cAMP measurements are global measurements of total cellular cAMP. However when biosensors are targeted to different subcellular domains, they often reveal more nuanced views of very localized cAMP signaling. There are many different AKAP Proteins that are localized to different regions of the cell. These AKAP Proteins bind the regulatory subunits of the PKA enzyme, but they often interact with adenyl cyclases, phosphodiesterases, and PKA substrates. This has led to the idea that they define “signalsomes” in the cell. To measure cAMP changes that occur in these singalsomes we have begun to fuse the cADDis cAMP biosensor to AKAP proteins.
Prototype sensors available now:
Recent studies describing spatially limited cAMP gradients, cAMP signaling pools, RAINs and signalsomes inspired us here at Montana Molecular. We created a new series of cADDis biosensors, enabling reliable measurements of cAMP signaling kinetics in various subcellular domains.
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#D0300R Red Down DAG Assay Kit
$895.00 – $1,795.00 -
Green Cell Stress Assay Kit #U0900G
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#D0800G Green GENIe cGMP Assay Kit
$895.00 – $1,795.00 -
#D0201G Green Cilia-targeted cADDis cAMP Assay Kit
$995.00 -
#D0400G Green PIP2 Assay Kit
$895.00 – $2,995.00 -
#D0400R Red PIP2 Assay Kit
$895.00 -
#C0500N Cre Recombinase
$995.00 -
#U0600R Red GECO Ca2+ Assay Kit
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Green/Red Ratiometric Cell Stress Assay Kit #U0901G
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#Z0400N Succinate Receptor 1
$995.00 -
#D0211G Ratiometric Cilia-Targeted cADDis cAMP Assay Kit
$995.00 -
#U0300R Red Up DAG Assay Kit
$895.00 – $1,795.00
Suggest the next AKAP/cADDis fusion sensor for development
GPCR Biology
Increase your understanding of drug effects and GPCR biology with bright fluorescent assays for Gs, Gi, and Gq signaling in living cells.
