Montana Molecular News
Differential Effects of GRK2 and GRK5 on Arrestin Recruitment Kinetics
Presented August 22nd at: The G Protein-coupled Receptor Kinases and Arrestins Conference: Key Modulators of Signal Transduction Although different GRK isoforms can enhance overall arrestin recruitment to specific GPCRs, the effect of each isoform on the kinetics of...
Environmental Impact of Basic Research
Greener Packaging Reducing the volume of plastics, styrofoam, and cardboard used in basic research can be a challenge, so we're taking steps to help. We switched the insulation in our packaging from styrofoam to biodegradable Green Cell...
Olfactory GPCRs Upregulated in Cancer
The Sweet Smell of a NobelThirty years ago, Linda Buck and Richard Axel described a large family of genes that encode what appeared to be G-protein coupled receptors, or GPCRs. These genes were expressed in the olfactory epithelium, and encoded an...
A Rapid and Sensitive Approach to Detecting SARS-CoV-2
There is a race in this pandemic to develop new technologies to detect SAR-CoV-2 virus and defeat its spread as quickly as possible. A bright light in this race recently appeared in a new paper published by Nanoscale Advances that describes a simple,...
Measuring partial and biased agonism at GPCRs on the FDSS/μCell
Kinetic analysis to measure agonist bias Montana Molecular’s genetically-encoded, fluorescent biosensors detect multiple receptor-mediated signaling pathways in real-time, live-cell assays. The kinetics of the responses for each signaling pathway can be used to...
The Neuroscience of Nausea
Nausea is a sense of malaise that all of us know. The sensation can be so overpowering that it leads us to wonder how and why this wretched condition happens
SARS-CoV-2 Variant Pseudoviruses
At Montana Molecular, we are committed to developing validated tools and services to support COVID-19 drug discovery. 2nd generation pseudoviruses for SARS-CoV-2 variants are on the way. Emerging SARS CoV-2 VariantsIn the spring of 2020, Manaus Brazil, was...
Covid 19 Drug Discovery Services
Functional Cell-based Assays Verified & Compound Libraries This unique platform is a powerful resource for researchers developing 3CLpro inhibitors and can streamline the development of safe and effective therapeutic treatments for...
Mpro inhibitor saves cats from certain death
Feline Infectious Peritonitis (FIP) is caused by a coronavirus. The 3CLpro of this virus is much like the one in SARS-CoV-2 and is crucial for viral replication. In 2016, Kim and colleagues showed that the compound GC376 blocked viral replication in cats...
SARS-CoV-2 Neutralization Assay
Screen neutralizing antibodies that inhibit SARS-CoV-2 host cell entry
