Dimerization Dependent Red Fluorescent Protein
Imagine the possibilities! In an impressive feat of rational engineering and directed evolution, Spencer C. Alford et.al. from Bob Campbell's lab at the University of Alberta developed ddRFP, a dimerization dependent bright new red that can be used to image...
Making the most of two photons
Excellent 3D resolution and minimal photobleaching made possible by multi photon microscopy are important advantages for fluorescence imaging in living cells. Until Misha Drobizhev et.al. tackled the issue, surprisingly little was known about the two photon absorption...
Multicolored Calcium Imaging
Looking for inspiration? Check out Yongzin Zhao's et.al's elegant paper on how the Campbell lab expanded the palette of genetically encoded calcium sensors that modulate fluorescence in response to changes in calcium. An Expanded Palette of Genetically Encoded Ca2+...
