Montana Molecular’s DAG sensor helped unravel the molecular mechanisms of TRPC6 cation channel activity which could lead to new treatments for TRPC6-associated diseases that affect cardiovascular and kidney dysfunction such as vasospasm and glomerulosclerosis. Researchers from Sasha Obukhov’s lab at Stark Neurosciences Research Institute and Indiana University used Montana Molecular’s sensors for DAG to study the role of the H1R histamine receptor in regulating TRPC6 activity. The paper, “PCK-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity” was just published in the MDPI open access journal Cells, for all to enjoy.
Figure from: Xingjuan Chen, Christian Egly, Ashley M. Riley, Wennan Li, Paul Tewson, Thomas E. Hughes, Anne Marie Quinn, and Alexander G. Obukhov (2014) PKC-dependent Phosphorylation of the H1 Histamine Receptor Modulates TRPC6 Activity. Cells (Basel, Switzerland), 3(2): 247-257; doi:10.3390/cells3020247.
