Human TMPRSS2 in BacMam for controlled expression in live mammalian cells and increased Spike binding.
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Useful BacMam Tools
BacMam tools Aside from fluorescent biosensors, Montana Molecular provides targeted fluorescent proteins, SARs-CoV-2 pseudoviruses, and expression vectors for GPCRs, ion channels, and many other drug targets. These tools are packaged in a BacMam viral vector,...
SARS-CoV-2 Host Factors
Host Cell Factors for SARS-CoV-2 Viral Entry Host Factors for Viral Entry Spike protein on SARS-CoV-2 interacts with the ACE2 receptor on the host cell to initiate viral entry, but other host factors are also involved. While ACE2 is necessary, it does not appear to...
SARS-CoV-2 Pseudovirus Entry Assay
Overview of SARS-CoV-2 Viral Entry The generally accepted model for SARS-CoV-2 viral entry involves two crucial elements: the Spike protein on the surface of the enveloped virus, and the host receptor ACE2. The Spike protein has a high...
SARS-CoV-2 Pseudovirus (Update)
Thank you for your interest in Montana Molecular’s assays for SARS-CoV-2 research and drug discovery. In a rapidly evolving field, as new insights into the mechanisms of viral entry come to light, we sincerely appreciate your patience and feedback as we continue to...
Scientific Publications
PublicationsPublications by Product E. Blythe, et al. Endocytosis sculpts distinct cAMP signal transduction by endogenously coexpressed GPCRs. bioRxiv preprint. February 2025. S. Orfanos, et al. The differential effects of cAMP mobilizing agents on inhibition of...
